Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 11/20 | 0.40 |
| ▸ | SSTR1 | P30872 | 6/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.39 |
| ▸ | NPY4R | P50391 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7266776 | 0.79 | HTR3A (0.55) | NOTUMHTR3ATSHR | |
| Hydrochloric Acid SCHEMBL7429564 | 0.78 | HTR3A (0.54) | HTR3ATSHR | |
| SCHEMBL27900168 | 0.78 | NOTUM (0.48) | NOTUMHTR3EHTR3BCHRNB2CHRNA7 | |
| SCHEMBL24317717 | 0.70 | ATM (0.44) | SSTR4SSTR1 | |
| SCHEMBL14834210 | 0.69 | MGLL (0.47) | HTR3EHTR3BCHRNB2CHRNA7CHRNA4 | |
| SCHEMBL5564015 | 0.69 | DRD2 (0.44) | — | |
| SCHEMBL6374063 | 0.68 | NOTUM (0.65) | NOTUMHTR3EHTR3BCHRNB2CHRNA7 | |
| SCHEMBL29373439 | 0.68 | NOTUM (0.65) | NOTUMHTR3EHTR3BCHRNB2CHRNA7 | |
| SCHEMBL28651838 | 0.68 | NOTUM (0.59) | NOTUMHTR3EHTR3BCHRNB2CHRNA7 | |
| SCHEMBL25053096 | 0.68 | CTSL (0.58) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1335917-A2 | CONDENSED PYRIDOINDOLE DERIVATIVES | Lilly Icos LLC (US) | 2003-08-20 | — | — | EP | claimed |
| WO-2002028859-A2 | CONDENSED PYRIDOINDOLE DERIVATIVES | LILLY ICOS LLC (US) | 2002-04-11 | — | — | WO | claimed |