Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.51 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL4435168 | 0.88 | MEN1 (0.51) | MEN1KMT2AALDH1A1HPGDAPOBEC3A | |
| Bicarbonate SCHEMBL6996704 | 0.87 | MEN1 (0.58) | MEN1KMT2AALDH1A1HPGDAPOBEC3A | |
| Bicarbonate SCHEMBL7615547 | 0.86 | LMNA (0.43) | MEN1KMT2AHPGDGAA | |
| Bicarbonate SCHEMBL6998215 | 0.85 | MEN1 (0.57) | MEN1KMT2AALDH1A1HPGDAPOBEC3A | |
| Bicarbonate SCHEMBL9119872 | 0.85 | HPGD (0.56) | MEN1KMT2AALDH1A1HPGDAPOBEC3A | |
| Bicarbonate SCHEMBL6996297 | 0.85 | SIGMAR1 (0.40) | MEN1KMT2AALDH1A1HPGDAPOBEC3A | |
| Bicarbonate SCHEMBL6990357 | 0.84 | MEN1 (0.71) | MEN1KMT2AALDH1A1HPGDAPOBEC3A | |
| Bicarbonate SCHEMBL6990325 | 0.84 | MEN1 (0.57) | MEN1KMT2AALDH1A1HPGDAPOBEC3A | |
| Bicarbonate SCHEMBL8554265 | 0.84 | LMNA (0.45) | HPGDSIGMAR1GAAEPHX2 | |
| Bicarbonate SCHEMBL6996071 | 0.83 | MEN1 (0.73) | MEN1KMT2AALDH1A1HPGDAPOBEC3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0754175-B1 | ALKOXY-ALKYL-SUBSTITUTED 1-H-3-ARYL-PYRROLIDINE-2,4-DIONES USED AS HERBICIDES AND PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2003-01-29 | — | — | EP | disclosed |