Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7615566 | 0.89 | SIGMAR1 (0.56) | LMNAP2RX7SIGMAR1MAPT | |
| Bicarbonate SCHEMBL7615547 | 0.88 | LMNA (0.43) | LMNAHPGDP2RX7GAANPC1 | |
| Bicarbonate SCHEMBL8558897 | 0.86 | LMNA (0.50) | LMNAHPGDSMN1; SMN2P2RX7SIGMAR1 | |
| Bicarbonate SCHEMBL4435470 | 0.85 | MEN1 (0.51) | LMNAHPGDSMN1; SMN2SIGMAR1GAA | |
| Bicarbonate SCHEMBL8553237 | 0.85 | LMNA (0.49) | LMNAHPGDSMN1; SMN2P2RX7SIGMAR1 | |
| Bicarbonate SCHEMBL6990352 | 0.84 | MEN1 (0.52) | HPGDSIGMAR1GAAEPHX2 | |
| Bicarbonate SCHEMBL8557459 | 0.84 | HPGD (0.62) | LMNAHPGDSMN1; SMN2P2RX7SIGMAR1 | |
| Bicarbonate SCHEMBL8554980 | 0.83 | SIGMAR1 (0.44) | LMNASMN1; SMN2P2RX7SIGMAR1MAPT | |
| Bicarbonate SCHEMBL8557002 | 0.83 | LMNA (0.60) | LMNAHPGDSMN1; SMN2SIGMAR1MAPT | |
| Bicarbonate SCHEMBL8553268 | 0.83 | LMNA (0.60) | LMNAHPGDSMN1; SMN2SIGMAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0668267-B1 | Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1998-04-08 | — | — | EP | disclosed |
| EP-0668267-A1 | Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1995-08-23 | — | — | EP | disclosed |