Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8554265 | 0.88 | LMNA (0.45) | LMNAHPGDP2RX7NPC1GAA | |
| Bicarbonate SCHEMBL8554980 | 0.88 | SIGMAR1 (0.44) | LMNAP2RX7NPC1RAB9AGAA | |
| Bicarbonate SCHEMBL6990352 | 0.86 | MEN1 (0.52) | HPGDGAAMEN1KMT2A | |
| Bicarbonate SCHEMBL7620865 | 0.86 | GAA (0.52) | LMNAHPGDP2RX7NPC1RAB9A | |
| Bicarbonate SCHEMBL7615143 | 0.84 | LMNA (0.47) | LMNAHPGDP2RX7NPC1RAB9A | |
| Bicarbonate SCHEMBL7622402 | 0.83 | KMT2A (0.38) | LMNAHPGDP2RX7TAS1R3TAS1R1 | |
| Bicarbonate SCHEMBL7621065 | 0.81 | ALPL (0.47) | LMNAHPGDP2RX7NPC1RAB9A | |
| Bicarbonate SCHEMBL7620489 | 0.81 | LMNA (0.46) | LMNAHPGDP2RX7NPC1RAB9A | |
| Bicarbonate SCHEMBL7614529 | 0.80 | LMNA (0.45) | LMNAHPGDP2RX7NPC1RAB9A | |
| Bicarbonate SCHEMBL7615566 | 0.79 | SIGMAR1 (0.56) | LMNAP2RX7KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0596298-B1 | 5-Spirosubstituted 1-H-3-aryl-pyrrolidin-2,4-dione derivatives as herbicides, insecticides and acaricides | BAYER AG (DE) | 2002-01-09 | — | — | EP | disclosed |
| EP-0596298-A2 | 5-Spirosubstituted 1-H-3-aryl-pyrrolidin-2,4-dione derivatives as herbicides, insecticides and acaricides | BAYER AG (DE) | 1994-05-11 | — | — | EP | disclosed |