Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2929686 | 0.93 | DRD3 (0.48) | DRD3HTR2ACYP19A1IDO1ADRA2A | |
| SCHEMBL599314 | 0.78 | CYP19A1 (0.54) | CYP19A1MTNR1AMTNR1BHTR1AGRIN2B | |
| SCHEMBL10145346 | 0.77 | HTR2A (0.57) | DRD3HTR2AHRH1CYP19A1IDO1 | |
| SCHEMBL3916886 | 0.74 | FYN (0.57) | DRD3HTR2AHRH1CYP19A1IDO1 | |
| SCHEMBL10245265 | 0.74 | PDPK1 (0.50) | HTR2AHRH1ADRA2A | |
| SCHEMBL18322481 | 0.74 | PNMT (0.41) | DRD3 | |
| SCHEMBL13880050 | 0.73 | DRD3 (0.44) | DRD3HTR2AHRH1CYP19A1IDO1 | |
| Hydrochloric Acid SCHEMBL18706948 | 0.72 | PNMT (0.40) | DRD3IDO1 | |
| SCHEMBL27520710 | 0.70 | HTR7 (0.51) | HTR1A | |
| SCHEMBL8354157 | 0.70 | SIGMAR1 (0.52) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368318-A2 | CALCILYTIC COMPOUNDS | SmithKline Beecham Corporation (US) | 2003-12-10 | — | — | EP | claimed |
| WO-2002007673-A2 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-31 | — | — | WO | claimed |
| EP-1368318-A2 | CALCILYTIC COMPOUNDS | SmithKline Beecham Corporation (US) | 2003-12-10 | — | — | EP | disclosed |
| EP-1148876-A4 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2003-07-23 | — | — | EP | disclosed |
| WO-2002007673-A2 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-31 | — | — | WO | disclosed |
| EP-1148876-A1 | CALCILYTIC COMPOUNDS | SmithKline Beecham Corporation (US) | 2001-10-31 | — | — | EP | disclosed |
| WO-2000045816-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (GB) | 2000-08-10 | — | — | WO | disclosed |