Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.40 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CCR5 | P51681 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985406 | 0.83 | ACHE (0.44) | CACNA2D1CACNA1BCACNB1MAPTMEN1 | |
| SCHEMBL4842101 | 0.80 | MEN1 (0.46) | CHRM2CHRM1CHRM3MAPTMEN1 | |
| SCHEMBL4832645 | 0.79 | CHRM2 (0.44) | CACNA2D1CACNA1BCACNB1CHRM2CHRM5 | |
| SCHEMBL6989033 | 0.77 | CACNA2D1 (0.45) | CACNA2D1CACNA1BCACNB1SIGMAR1MEN1 | |
| SCHEMBL4838599 | 0.75 | KDM4E (0.44) | CACNA2D1CACNA1BCACNB1CHRM2CHRM1 | |
| SCHEMBL6580060 | 0.74 | KCNA3 (0.47) | CTSLMAPTCCR5MEN1KMT2A | |
| SCHEMBL6369665 | 0.74 | ALDH1A1 (0.47) | CHRM2CHRM5CHRM1CHRM3SIGMAR1 | |
| SCHEMBL4385892 | 0.73 | SMN1; SMN2 (0.42) | CTSLSIGMAR1MEN1KMT2ANPSR1 | |
| SCHEMBL4840733 | 0.72 | KDM4E (0.46) | CHRM2CHRM5CHRM1CHRM3SIGMAR1 | |
| SCHEMBL5868123 | 0.72 | ITGB3 (0.40) | ITGB3ITGA2BCHRM2CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289972-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001096323-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |