Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.45 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.45 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990562 | 0.77 | CACNA2D1 (0.40) | CACNA2D1CACNA1BCACNB1SIGMAR1GPR119 | |
| SCHEMBL4844156 | 0.75 | GPR119 (0.55) | SIGMAR1GPR119ALDH1A1KDM4EHTT | |
| SCHEMBL6985406 | 0.75 | ACHE (0.44) | CACNA2D1CACNA1BCACNB1GPR119ALDH1A1 | |
| SCHEMBL6988541 | 0.75 | SIGMAR1 (0.35) | SIGMAR1 | |
| SCHEMBL6299819 | 0.73 | KCNA3 (0.53) | SIGMAR1GPR119ALDH1A1MEN1TSHR | |
| SCHEMBL4382303 | 0.73 | HPGD (0.38) | SIGMAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL10282674 | 0.72 | POLB (0.58) | SIGMAR1ALDH1A1KDM4EHTTRAB9A | |
| SCHEMBL7797107 | 0.71 | NPR3 (0.42) | GPR119TSHRKMT2AL3MBTL1 | |
| SCHEMBL4838884 | 0.71 | KDM4E (0.54) | CACNA2D1CACNA1BCACNB1SIGMAR1GPR119 | |
| SCHEMBL6580060 | 0.70 | KCNA3 (0.47) | ALDH1A1MEN1TSHRKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289972-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001096323-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |