Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 3/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 6/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 3/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990381 | 0.94 | HTR1A (0.49) | ADRA1DADRA1AADRA1BDRD4HTR1A | |
| SCHEMBL6984315 | 0.94 | HTR1A (0.49) | ADRA1DADRA1AADRA1BDRD4HTR1A | |
| SCHEMBL6991218 | 0.93 | HTR1A (0.50) | HTR1ADRD2HTR7DRD5DRD3 | |
| SCHEMBL6988196 | 0.93 | HTR1A (0.50) | HTR1ADRD2HTR7DRD5DRD3 | |
| SCHEMBL6993124 | 0.88 | HTR1A (0.49) | ADRA1DADRA1AADRA1BDRD4HTR1A | |
| SCHEMBL6990399 | 0.86 | ADRA2A (0.46) | ADRA1BDRD4HTR1AHTR7 | |
| SCHEMBL6989705 | 0.82 | L3MBTL1 (0.41) | — | |
| SCHEMBL6991433 | 0.80 | L3MBTL1 (0.39) | — | |
| SCHEMBL9041354 | 0.80 | L3MBTL1 (0.39) | HTR1AHTR7 | |
| SCHEMBL6994151 | 0.80 | HTR1A (0.50) | DRD4HTR1ADRD2HTR7DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0551527-B1 | PYRROLOAZEPINE DERIVATIVE | SUNTORY LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-5397780-A | Antiserotonine, hypotensive, congestive heart failure | SUNTORY LIMITED (JP) | 1995-03-14 | — | — | US | disclosed |
| EP-0551527-A1 | PYRROLOAZEPINE DERIVATIVE | SUNTORY LIMITED (JP) | 1993-07-21 | — | — | EP | disclosed |