Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.50 |
| ▸ | HTR7 | P34969 | 5/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988196 | 1.00 | HTR1A (0.50) | HTR1AHTR7KCNH2DRD2DRD3 | |
| SCHEMBL6984315 | 0.99 | HTR1A (0.49) | HTR1AHTR7KCNH2DRD2DRD3 | |
| SCHEMBL6990381 | 0.97 | HTR1A (0.49) | HTR1AHTR7KCNH2DRD2DRD3 | |
| SCHEMBL6990656 | 0.93 | ADRA1D (0.47) | HTR1AHTR7DRD2DRD3DRD5 | |
| SCHEMBL6993124 | 0.89 | HTR1A (0.49) | HTR1AHTR7KCNH2DRD2DRD3 | |
| SCHEMBL9266055 | 0.85 | HTR1A (0.54) | HTR1AHTR7KCNH2DRD2DRD3 | |
| SCHEMBL6989882 | 0.85 | DRD3 (0.57) | HTR1AHTR7DRD2DRD3DRD5 | |
| SCHEMBL6987269 | 0.84 | L3MBTL1 (0.38) | HTR1AHTR7 | |
| SCHEMBL6986608 | 0.84 | L3MBTL1 (0.38) | HTR1AHTR7 | |
| SCHEMBL6986161 | 0.84 | HTR1A (0.53) | HTR1AHTR7KCNH2DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0551527-B1 | PYRROLOAZEPINE DERIVATIVE | SUNTORY LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-5397780-A | Antiserotonine, hypotensive, congestive heart failure | SUNTORY LIMITED (JP) | 1995-03-14 | — | — | US | disclosed |
| EP-0551527-A1 | PYRROLOAZEPINE DERIVATIVE | SUNTORY LIMITED (JP) | 1993-07-21 | — | — | EP | disclosed |