Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.36 |
| ▸ | LSS | P48449 | 7/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6049347 | 0.78 | GABRA1 (0.44) | GABRA1GABRB2 | |
| SCHEMBL6648434 | 0.77 | GABRA1 (0.46) | GABRA1GABRB2NR4A2 | |
| SCHEMBL6986923 | 0.77 | NR4A2 (0.40) | GABRA1GABRB2NR4A2 | |
| SCHEMBL6647509 | 0.73 | NR4A2 (0.49) | LMNAMAPTGABRA1GABRB2NR4A2 | |
| SCHEMBL6652006 | 0.73 | ALDH1A1 (0.46) | ALDH1A1LMNAMAPTHIF1AGABRA1 | |
| SCHEMBL7218485 | 0.72 | LSS (0.36) | LSSMEN1KMT2A | |
| SCHEMBL6649109 | 0.71 | NR4A2 (0.47) | LMNAMAPTGABRA1NR4A2MEN1 | |
| SCHEMBL5734736 | 0.70 | OXER1 (0.42) | LSS | |
| SCHEMBL6988448 | 0.70 | LSS (0.35) | LSSMEN1KMT2A | |
| SCHEMBL5635775 | 0.70 | DHODH (0.47) | LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349833-A1 | INDOLE AND DIHYDROINDOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002044149-A1 | INDOLE AND DIHYDROINDOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-06 | — | — | WO | disclosed |