Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.37 |
| ▸ | HTR1B | P28222 | 2/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6647187 | 0.92 | ALDH1A1 (0.52) | ALDH1A1MAPTL3MBTL1GABRA1GABRB2 | |
| SCHEMBL6676999 | 0.81 | GABRA1 (0.47) | ALDH1A1GABRA1GABRB2LMNAPOLB | |
| SCHEMBL6650264 | 0.80 | GABRA1 (0.45) | ALDH1A1GABRA1GABRB2POLBNR4A2 | |
| SCHEMBL6648434 | 0.79 | GABRA1 (0.46) | GABRA1GABRB2NR4A2 | |
| SCHEMBL6647509 | 0.75 | NR4A2 (0.49) | MAPTGABRA1GABRB2LMNANR4A2 | |
| SCHEMBL6990824 | 0.73 | ALDH1A1 (0.39) | ALDH1A1MAPTGABRA1GABRB2LMNA | |
| SCHEMBL6651435 | 0.72 | KDM4E (0.44) | ALDH1A1MAPTL3MBTL1GABRA1GABRB2 | |
| SCHEMBL6645714 | 0.71 | NR4A2 (0.39) | ALDH1A1GABRA1GABRB2LMNANR4A2 | |
| SCHEMBL6049347 | 0.71 | GABRA1 (0.44) | GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL6649505 | 0.70 | NR4A2 (0.47) | MAPTGABRA1GABRB2NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474425-A1 | DEAZAPURINES AND USES THEREOF | Eisai Co. Ltd. (JP) | 2004-11-10 | — | — | EP | disclosed |
| WO-2004063336-A2 | USES OF DEAZAPURINES FOR THE TREATMENT OF REPERFUSION INJURIES, OSTEOPOROSIS AND/OR BONE METASTASIS | EISAI CO. LTD. (JP) | 2004-07-29 | — | — | WO | disclosed |
| WO-2003057696-A1 | DEAZAPURINES AND USES THEREOF | EISAI CO. LTD. (JP) | 2003-07-17 | — | — | WO | disclosed |