Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 4/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6049347 | 0.81 | GABRA1 (0.44) | GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL6648434 | 0.80 | GABRA1 (0.46) | NR4A2GABRA1GABRB2 | |
| SCHEMBL6990824 | 0.77 | ALDH1A1 (0.39) | NR4A2GABRA1GABRB2 | |
| SCHEMBL6647509 | 0.77 | NR4A2 (0.49) | NR4A2GABRA1GABRB2 | |
| SCHEMBL9720181 | 0.75 | CA12 (0.45) | — | |
| SCHEMBL6986880 | 0.72 | NR4A2 (0.72) | NR4A2GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL6676999 | 0.72 | GABRA1 (0.47) | NR4A2GABRA1GABRB2 | |
| SCHEMBL6649505 | 0.72 | NR4A2 (0.47) | NR4A2GABRA1GABRB2 | |
| SCHEMBL8567015 | 0.71 | CA1 (0.46) | — | |
| SCHEMBL6630345 | 0.71 | NR4A2 (0.49) | NR4A2GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349833-A1 | INDOLE AND DIHYDROINDOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002044149-A1 | INDOLE AND DIHYDROINDOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-06 | — | — | WO | disclosed |