Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13344651 | 0.91 | NR4A2 (0.45) | NR4A2ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL6984696 | 0.79 | TRPM8 (0.47) | ALDH1A1KDM4EHPGDHSD17B10HTT | |
| SCHEMBL4561758 | 0.78 | NR4A2 (0.71) | NR4A2ALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL12758944 | 0.77 | NR4A2 (0.38) | NR4A2ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL14367890 | 0.77 | ALDH1A1 (0.59) | ALDH1A1POLB | |
| SCHEMBL14440308 | 0.77 | NR4A2 (0.53) | NR4A2ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL8352535 | 0.77 | NR4A2 (0.72) | NR4A2ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL5972910 | 0.75 | EGFR (0.63) | ALDH1A1KDM4EKMT2AMEN1HPGD | |
| SCHEMBL13794397 | 0.75 | NR4A2 (0.44) | NR4A2ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL7474876 | 0.74 | NR4A2 (0.61) | NR4A2ALDH1A1KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1283836-A2 | NEUROPROTECTIVE AND ANTI-PROLIFERATIVE COMPOUNDS | Aegera Therapeutics Inc. (CA) | 2003-02-19 | — | — | EP | disclosed |
| WO-2001087887-A2 | NEUROPROTECTIVE AND ANTI-PROLIFERATIVE COMPOUNDS | AEGERA THERAPEUTICS INC. (CA) | 2001-11-22 | — | — | WO | disclosed |