Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 7/20 | 0.59 |
| ▸ | DRD2 | P14416 | 6/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.59 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.59 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.59 |
| ▸ | DRD1 | P21728 | 4/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.59 |
| ▸ | HTR2A | P28223 | 4/20 | 0.59 |
| ▸ | HTR2C | P28335 | 4/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.59 |
| ▸ | HRH1 | P35367 | 4/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.59 |
| ▸ | HTR2B | P41595 | 4/20 | 0.59 |
| ▸ | DRD4 | P21917 | 3/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998870 | 0.84 | CHRM1 (0.60) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL6994687 | 0.83 | CHRM1 (0.59) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL6995640 | 0.80 | DRD2 (0.61) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL6990005 | 0.80 | DRD2 (0.61) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL6989889 | 0.77 | DRD2 (0.57) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL6991310 | 0.77 | DRD2 (0.61) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL6990235 | 0.77 | LMNA (0.38) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL6996513 | 0.76 | CHRM1 (0.44) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL6990101 | 0.76 | CHRM1 (0.53) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL6991010 | 0.76 | DRD2 (0.53) | CHRM1DRD2CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1016664-B1 | FUSED THIOPHENE COMPOUNDS AND MEDICINAL USE THEREOF | MITSUBISHI PHARMA CORP (JP) | 2003-07-02 | — | — | EP | claimed |
| US-20020042411-A1 | Condensed thiophene compounds and pharmaceutical use thereof | MITSUBISHI PHARMA CORPORATION (JP) | 2002-04-11 | — | — | US | claimed |
| US-6271225-B1 | PSYCHOLOGICAL DISORDERS | WELFIDE CORPORATION (JP) | 2001-08-07 | — | — | US | claimed |
| EP-1016664-A1 | FUSED THIOPHENE COMPOUNDS AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2000-07-05 | — | — | EP | claimed |
| EP-1016664-B1 | FUSED THIOPHENE COMPOUNDS AND MEDICINAL USE THEREOF | MITSUBISHI PHARMA CORP (JP) | 2003-07-02 | — | — | EP | disclosed |
| US-6455521-B1 | PSYCHOLOGICAL DISORDERS; SIDE EFFECT REDUCTION | MITSUBISHI PHARMA CORPORATION (JP) | 2002-09-24 | — | — | US | disclosed |
| US-20020042411-A1 | Condensed thiophene compounds and pharmaceutical use thereof | MITSUBISHI PHARMA CORPORATION (JP) | 2002-04-11 | — | — | US | disclosed |
| US-6271225-B1 | PSYCHOLOGICAL DISORDERS | WELFIDE CORPORATION (JP) | 2001-08-07 | — | — | US | disclosed |
| EP-1016664-A1 | FUSED THIOPHENE COMPOUNDS AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2000-07-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020042411-A1 | Condensed thiophene compounds and pharmaceutical use thereof | ACIN1, ACHE, TPMT | CHRM1 26/4885DRD2 620/4885CHRM2 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.