Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL7808419 | 0.94 | RAD52 (0.38) | RAD52THRBNR4A1SLC2A1RAD51 | |
| Potassium Ion SCHEMBL6996169 | 0.92 | RAD52 (0.39) | RAD52NR4A1CDYLKDM4E | |
| SCHEMBL8192669 | 0.86 | RAD52 (0.44) | RAD52SLC2A1KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL7002514 | 0.85 | RAD52 (0.43) | RAD52SLC2A1KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL6991493 | 0.85 | RAD52 (0.43) | RAD52SLC2A1KEAP1NFE2L2ALDH1A1 | |
| Potassium Ion SCHEMBL6991427 | 0.82 | RAD52 (0.41) | RAD52THRBRAD51ALDH1A1KDM4E | |
| SCHEMBL7810046 | 0.80 | RAD52 (0.39) | RAD52SLC2A1KEAP1NFE2L2ALDH1A1 | |
| Potassium Ion SCHEMBL7805908 | 0.78 | RAD52 (0.38) | RAD52THRBRAD51 | |
| SCHEMBL6996170 | 0.77 | CYP1A2 (0.43) | RAD52SLC2A1CDYL | |
| SCHEMBL6203760 | 0.75 | CCR8 (0.39) | RAD52ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028962-B1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO INC (US) | 2003-04-23 | — | — | EP | disclosed |
| EP-1023062-B1 | ANTIBACTERIAL CARBAPENEMS, COMPOSITIONS AND METHODS OF TREATMENT | MERCK & CO INC (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6399597-B1 | CARBAPENICILLIN ANTIBIOTICS | MERCK & CO., INC. | 2002-06-04 | — | — | US | disclosed |
| EP-1028962-A4 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-1032383-A4 | ANTIBACTERIAL CARBAPENEMS, COMPOSITIONS AND METHODS OF TREATMEMT | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-1023062-A4 | ANTIBACTERIAL CARBAPENEMS, COMPOSITIONS AND METHODS OF TREATMENT | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-6294529-B1 | ANTIBIOTICS BACTERICIDES | MERCK & CO., INC. | 2001-09-25 | — | — | US | disclosed |
| EP-1027352-A4 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | MERCK & CO INC (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6140318-A | FOR TREATING BACTERIAL INFECTIONS | MERCK & CO., INC. (US) | 2000-10-31 | — | — | US | disclosed |
| EP-1032383-A1 | ANTIBACTERIAL CARBAPENEMS, COMPOSITIONS AND METHODS OF TREATMEMT | Merck & Co., Inc. (US) | 2000-09-06 | — | — | EP | disclosed |
| EP-1028962-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| EP-1027352-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2000-08-16 | — | — | EP | disclosed |
| EP-1023062-A1 | ANTIBACTERIAL CARBAPENEMS, COMPOSITIONS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2000-08-02 | — | — | EP | disclosed |
| US-6008212-A | ANTIBIOTICS AGAINST METHICILLIN RESISTANT STAPHYLOCOCCI | MERCK & CO., INC. (US) | 1999-12-28 | — | — | US | disclosed |
| US-5994345-A | ANTIBIOTICS | MERCK & CO., INC. (US) | 1999-11-30 | — | — | US | disclosed |
| WO-1999020269-A1 | ANTIBACTERIAL CARBAPENEMS, COMPOSITIONS AND METHODS OF TREATMEMT | MERCK & CO., INC. (US) | 1999-04-29 | — | — | WO | disclosed |
| WO-1999020627-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 1999-04-29 | — | — | WO | disclosed |
| WO-1999020628-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 1999-04-29 | — | — | WO | disclosed |
| WO-1999018954-A1 | ANTIBACTERIAL CARBAPENEMS, COMPOSITIONS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 1999-04-22 | — | — | WO | disclosed |