Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991119 | 0.92 | MAPK1 (0.42) | HSD17B10ALOX15PARP1MAPK1L3MBTL1 | |
| SCHEMBL6998253 | 0.87 | PARP1 (0.54) | HSD17B10ALOX15PARP1NR3C2 | |
| SCHEMBL6992162 | 0.78 | PARP1 (0.55) | HSD17B10PARP1MAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL26311050 | 0.75 | L3MBTL1 (0.53) | HSD17B10ALOX15PARP1MAPK1L3MBTL1 | |
| SCHEMBL26310974 | 0.75 | PARP1 (0.53) | HSD17B10ALOX15PARP1MAPK1L3MBTL1 | |
| SCHEMBL7001780 | 0.73 | NR3C2 (0.34) | NR3C2 | |
| SCHEMBL26310973 | 0.73 | PARP1 (0.49) | HSD17B10ALOX15PARP1MAPK1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL6988645 | 0.72 | NR3C2 (0.33) | NR3C2 | |
| Hydrochloric Acid SCHEMBL6992625 | 0.72 | NR3C2 (0.32) | PARP1NR3C2 | |
| SCHEMBL7003159 | 0.71 | PARP1 (0.74) | HSD17B10ALOX15PARP1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015437-B1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING AG (DE) | 2003-12-03 | — | — | EP | disclosed |
| US-6365736-B1 | TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-02 | — | — | US | disclosed |