Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 13/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000442 | 1.00 | PTGES (0.56) | PTGESALOX5MEN1KMT2APTGS1 | |
| SCHEMBL7005247 | 0.89 | ALOX5 (0.46) | PTGESALOX5MEN1KMT2APTGS1 | |
| SCHEMBL6999924 | 0.88 | PTGES (0.53) | PTGESALOX5MEN1KMT2APTGS1 | |
| SCHEMBL7003600 | 0.88 | PTGES (0.56) | PTGESALOX5PTGS1THRBALOX5AP | |
| SCHEMBL7003381 | 0.88 | PTGES (0.56) | PTGESALOX5PTGS1THRBALOX5AP | |
| SCHEMBL7003945 | 0.86 | PTGS2 (0.44) | PTGESALOX5MEN1KMT2APTGS1 | |
| SCHEMBL7003650 | 0.86 | PTGS2 (0.44) | PTGESALOX5MEN1KMT2APTGS1 | |
| SCHEMBL7003832 | 0.85 | PTGES (0.55) | PTGESALOX5PTGS1LMNASMN1; SMN2 | |
| SCHEMBL6486937 | 0.81 | PTGES (0.58) | PTGESALOX5MEN1KMT2APTGS1 | |
| SCHEMBL6484148 | 0.81 | PTGES (0.58) | PTGESALOX5MEN1KMT2APTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246825-B1 | FUSED PYRROLE COMPOUNDS, PHARMACEUTICAL AGENTS CONTAINING THE SAME, AND THE USE THEREOF | MERCKLE GMBH (DE) | 2003-12-17 | — | — | EP | disclosed |