Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.43 |
| ▸ | CBFB | Q13951 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.35 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27879461 | 0.75 | ALDH1A1 (0.40) | ALDH1A1HTTHPGDGAAMAPT | |
| SCHEMBL9135064 | 0.72 | HPGD (0.67) | ALDH1A1HTTHPGDGAAMAPT | |
| SCHEMBL6993258 | 0.72 | ALDH1A1 (0.47) | ALDH1A1HTTHPGDGAAMAPT | |
| SCHEMBL8461890 | 0.71 | IDO1 (0.42) | ALDH1A1LMNAKMT2AMEN1THRB | |
| SCHEMBL249552 | 0.71 | KMT2A (0.71) | ALDH1A1HTTHPGDGAALMNA | |
| SCHEMBL31175932 | 0.71 | KMT2A (0.71) | ALDH1A1HTTHPGDGAALMNA | |
| SCHEMBL872856 | 0.69 | ALDH1A1 (0.45) | ALDH1A1HPGDGAAMAPTLMNA | |
| SCHEMBL1094712 | 0.69 | ALDH1A1 (0.45) | ALDH1A1HTTHPGDGAAMAPT | |
| SCHEMBL2659245 | 0.69 | BCAT2 (0.49) | ALDH1A1HTTHPGDGAAMAPT | |
| SCHEMBL10546968 | 0.69 | ALDH1A1 (0.49) | ALDH1A1HTTHPGDGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370536-A1 | METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2003-12-17 | — | — | EP | disclosed |
| EP-1370538-A1 | METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002074752-A1 | METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |
| WO-2002074750-A1 | METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |