Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL6993373

O=C(O)C(F)(F)F.O=C(O)COc1ncccn1

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.42
SMN1; SMN2 Q16637 3/20 0.40
PKM P14618 1/20 0.40
TSHR P16473 1/20 0.40
LMNA P02545 1/20 0.39
KMT2A Q03164 2/20 0.38
HIF1A Q16665 1/20 0.38
PTGDR2 Q9Y5Y4 1/20 0.38
CD69 Q07108 2/20 0.37
POLB P06746 1/20 0.37
GLA P06280 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
MEN1 O00255 1/20 0.37
FFAR4 Q5NUL3 1/20 0.36
KDM4E B2RXH2 1/20 0.36
CYP1A2 P05177 1/20 0.36
MAPT P10636 1/20 0.36
PTPN7 P35236 1/20 0.36
FFAR1 O14842 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1280673 0.88 ALOX15 (0.52) ALOX15SMN1; SMN2LMNAKMT2AHIF1A
Trifluoroacetic Acid SCHEMBL11354737 0.76 ALOX15 (0.77) ALOX15SMN1; SMN2LMNAKMT2AMEN1
SCHEMBL6993377 0.75 TDP1 (0.31) TSHR
Trifluoroacetic Acid SCHEMBL2413465 0.74 ALOX15 (0.51) ALOX15SMN1; SMN2LMNAL3MBTL1MAPT
Trifluoroacetic Acid SCHEMBL6990821 0.73 PKM (0.42) ALOX15SMN1; SMN2PKMTSHRLMNA
Trifluoroacetic Acid SCHEMBL30018844 0.70 L3MBTL1 (0.40) ALOX15TSHRLMNAKMT2AL3MBTL1
Trifluoroacetic Acid SCHEMBL4060317 0.70 HSP90AA1 (0.55) ALOX15TSHRLMNAL3MBTL1KDM4E
Trifluoroacetic Acid SCHEMBL38653278 0.70 L3MBTL1 (0.40) ALOX15TSHRLMNAKMT2AL3MBTL1
SCHEMBL5859013 0.70 MAPT (0.49) KMT2APOLBGLAL3MBTL1MEN1
SCHEMBL16741032 0.69 L3MBTL1 (0.47) ALOX15SMN1; SMN2PKMPTGDR2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1339692-A1 NOVEL COMPOUNDS FOR USE AS HIV PROTEASE INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2003-09-03 EP disclosed
US-6472404-B1 HIV protease inhibitors HOFFMANN-LA ROCHE INC. 2002-10-29 US disclosed
WO-2002042277-A1 NOVEL COMPOUNDS FOR USE AS HIV PROTEASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2002-05-30 WO disclosed