SCHEMBL69937

SCHEMBL69937

COC(=O)c1ccc2oc3ccc(C(=O)OC)cc3c(=O)c2c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.58
RAB9A P51151 3/20 0.58
TTR P02766 4/20 0.55
KDM4E B2RXH2 3/20 0.54
ALDH1A1 P00352 3/20 0.54
HPGD P15428 3/20 0.54
MAPT P10636 3/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
CASP3 P42574 1/20 0.54
SENP8 Q96LD8 1/20 0.54
SENP7 Q9BQF6 1/20 0.54
SENP6 Q9GZR1 1/20 0.54
CREBBP Q92793 1/20 0.53
HSD17B10 Q99714 2/20 0.51
MEN1 O00255 1/20 0.51
TP53 P04637 1/20 0.51
CYP2C9 P11712 1/20 0.51
PTGER1 P34995 1/20 0.51
PTGER3 P43115 1/20 0.51
PTGER2 P43116 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11319698 0.94 KDM4E (0.56) NPC1RAB9ATTRKDM4EALDH1A1
SCHEMBL11319692 0.92 NPC1 (0.71) NPC1RAB9ATTRKDM4EALDH1A1
SCHEMBL68516 0.91 CA1 (0.53) NPC1RAB9AKDM4EALDH1A1HPGD
SCHEMBL11868305 0.89 NPC1 (0.66) NPC1RAB9ATTRKDM4EALDH1A1
SCHEMBL11866301 0.89 THRB (0.54) NPC1RAB9ATTRKDM4EALDH1A1
SCHEMBL8949520 0.89 MAOA (0.56) NPC1RAB9ATTRKDM4EALDH1A1
SCHEMBL20317213 0.89 NPC1 (0.55) NPC1RAB9ATTRKDM4EALDH1A1
SCHEMBL11860960 0.86 KMT2A (0.50) NPC1RAB9ATTRKDM4EALDH1A1
SCHEMBL17819836 0.86 CSNK2A1 (0.50) NPC1RAB9ATTRKDM4EALDH1A1
SCHEMBL3966330 0.86 CREBBP (0.56) NPC1RAB9ATTRKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2479203-A1 AROMATIC POLYESTER Muroran Institute of Technology (JP) 2012-07-25 EP disclosed
US-20120172570-A1 AROMATIC POLYESTER NITTA CORPORATION 2012-07-05 US disclosed
US-8129493-B2 Aromatic polyester MURORAN INSTITUTE OF TECHNOLOGY (JP) 2012-03-06 US disclosed
US-20110224343-A1 MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME MURORAN INSTITUTE OF TECHNOLOGY (JP) 2011-09-15 US disclosed
US-20110092662-A1 AROMATIC POLYESTER NITTA CORPORATION (JP) 2011-04-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110224343-A1 MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME F12, PHAX, WDR82 NPC1 4583/4885RAB9A 3169/4885TTR 3513/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.