Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.35 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.35 |
| ▸ | DRD1 | P21728 | 4/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.35 |
| ▸ | HTR2C | P28335 | 4/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.35 |
| ▸ | HRH1 | P35367 | 4/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.35 |
| ▸ | HTR2B | P41595 | 4/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14156629 | 0.80 | LMNA (0.36) | LMNAGAACHRM2CHRM4CHRM5 | |
| SCHEMBL6990235 | 0.80 | LMNA (0.38) | LMNAGAACHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL4836312 | 0.79 | LMNA (0.35) | LMNAGAACHRM2CHRM4CHRM5 | |
| SCHEMBL6994687 | 0.77 | CHRM1 (0.59) | LMNAGAACHRM2CHRM4CHRM5 | |
| SCHEMBL6991775 | 0.74 | POLB (0.40) | MEN1KMT2AMAPTMCL1 | |
| SCHEMBL6998543 | 0.71 | BACE1 (0.35) | LMNAGAACHRM2CHRM4CHRM5 | |
| SCHEMBL7001273 | 0.71 | DRD2 (0.35) | LMNAGAACHRM2CHRM4CHRM5 | |
| SCHEMBL79367 | 0.69 | DRD2 (0.58) | LMNAGAACHRM2CHRM4CHRM5 | |
| SCHEMBL4845499 | 0.69 | LMNA (0.41) | LMNAGAACHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL937256 | 0.68 | DRD2 (0.57) | LMNAGAACHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1016664-B1 | FUSED THIOPHENE COMPOUNDS AND MEDICINAL USE THEREOF | MITSUBISHI PHARMA CORP (JP) | 2003-07-02 | — | — | EP | disclosed |
| EP-1016664-A1 | FUSED THIOPHENE COMPOUNDS AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2000-07-05 | — | — | EP | disclosed |