Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.35 |
| ▸ | DRD4 | P21917 | 3/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 7/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.32 |
| ▸ | HTR2A | P28223 | 5/20 | 0.32 |
| ▸ | HTR2C | P28335 | 5/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.32 |
| ▸ | HRH1 | P35367 | 5/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.32 |
| ▸ | HTR2B | P41595 | 5/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998543 | 0.85 | BACE1 (0.35) | DRD2CHRM1DRD4DRD3MAPT | |
| SCHEMBL14156629 | 0.84 | LMNA (0.36) | DRD2CHRM1DRD4DRD3MAPT | |
| Hydrochloric Acid SCHEMBL4836312 | 0.83 | LMNA (0.35) | DRD2CHRM1DRD4DRD3MAPT | |
| SCHEMBL6991310 | 0.77 | DRD2 (0.61) | DRD2CHRM1DRD4DRD3MAPT | |
| SCHEMBL6994826 | 0.76 | CHEK1 (0.47) | MAPTNPC1RAB9ALMNAMEN1 | |
| SCHEMBL6996940 | 0.74 | AXL (0.34) | MAPTLMNAHTR5AGFERBCKDK | |
| SCHEMBL6994128 | 0.72 | IDO1 (0.34) | CHRM1MAPTRAB9AHRH1MEN1 | |
| SCHEMBL4836633 | 0.72 | MAPT (0.34) | MAPTRAB9AHTR5AGFERSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4843553 | 0.72 | MAPT (0.34) | MAPTRAB9AHTR5ASMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4843411 | 0.72 | IDO1 (0.33) | CHRM1MAPTRAB9AHRH1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1016664-B1 | FUSED THIOPHENE COMPOUNDS AND MEDICINAL USE THEREOF | MITSUBISHI PHARMA CORP (JP) | 2003-07-02 | — | — | EP | disclosed |
| US-6455521-B1 | PSYCHOLOGICAL DISORDERS; SIDE EFFECT REDUCTION | MITSUBISHI PHARMA CORPORATION (JP) | 2002-09-24 | — | — | US | disclosed |
| EP-1016664-A1 | FUSED THIOPHENE COMPOUNDS AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2000-07-05 | — | — | EP | disclosed |