Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997494 | 0.90 | HTR1A (0.47) | DRD2DRD4HTR7HTR1AHTR2A | |
| SCHEMBL7496420 | 0.84 | LMNA (0.46) | KDM4ELMNAMAPK1DRD2DRD4 | |
| SCHEMBL6622902 | 0.84 | LMNA (0.46) | KDM4ELMNAMAPK1DRD2DRD4 | |
| SCHEMBL6622904 | 0.84 | LMNA (0.46) | KDM4ELMNAMAPK1DRD2DRD4 | |
| SCHEMBL6774305 | 0.82 | KDM4E (0.46) | KDM4ELMNAMAPK1DRD2DRD4 | |
| SCHEMBL6769738 | 0.82 | DRD2 (0.44) | KDM4ELMNAMAPK1DRD2DRD4 | |
| SCHEMBL6773782 | 0.80 | KDM4E (0.44) | KDM4ELMNAMAPK1DRD2DRD4 | |
| SCHEMBL6653693 | 0.78 | DRD2 (0.43) | KDM4ELMNAMAPK1DRD2DRD4 | |
| SCHEMBL6995879 | 0.78 | KDM4E (0.48) | KDM4ELMNAMAPK1DRD2DRD4 | |
| SCHEMBL6774449 | 0.78 | KDM4E (0.44) | KDM4ELMNAMAPK1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0557526-B1 | PYRROLOAZEPINE COMPOUND | SUNTORY LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-5399557-A | Cardiovascular disorders | SUNTORY LIMITED (JP) | 1995-03-21 | — | — | US | disclosed |
| EP-0557526-A1 | PYRROLOAZEPINE COMPOUND | SUNTORY LIMITED (JP) | 1993-09-01 | — | — | EP | disclosed |