Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993342 | 0.91 | KMT2A (0.40) | KMT2AATMHTTIDO1ALDH1A1 | |
| SCHEMBL6994214 | 0.88 | MEN1 (0.36) | KMT2AALDH1A1LMNAMAPTNPC1 | |
| SCHEMBL6993081 | 0.88 | CTSK (0.35) | KMT2ALMNAMAPTNPC1RAB9A | |
| SCHEMBL6988915 | 0.87 | IDO1 (0.42) | KMT2AATMHTTIDO1ALDH1A1 | |
| SCHEMBL6993839 | 0.86 | HTR1A (0.39) | KMT2AMAPK1ALDH1A1LMNAKDM4E | |
| SCHEMBL6295728 | 0.83 | CTSL (0.36) | KMT2ANLRP3IDO1LMNARAB9A | |
| SCHEMBL6989479 | 0.82 | ATM (0.39) | KMT2AATMHTTPRMT5MAPK1 | |
| SCHEMBL6998484 | 0.81 | TRPV1 (0.39) | — | |
| SCHEMBL6699096 | 0.79 | CTSL (0.45) | KMT2AIDO1 | |
| SCHEMBL6997966 | 0.79 | MEN1 (0.34) | KMT2AALDH1A1TSHRMDM2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358176-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057246-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |