Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993342 | 0.93 | KMT2A (0.40) | IDO1KMT2ATP53LMNAPTGDR2 | |
| SCHEMBL6991739 | 0.90 | TRPV1 (0.38) | TP53LMNAPTGDR2 | |
| SCHEMBL6994067 | 0.88 | RAB9A (0.41) | IDO1KMT2ATP53LMNAPTGDR2 | |
| SCHEMBL6990244 | 0.88 | TP53 (0.38) | IDO1KMT2ATP53PTGDR2THRB | |
| SCHEMBL6989614 | 0.86 | TP53 (0.47) | KMT2ATP53LMNATHRBSMN1; SMN2 | |
| SCHEMBL6988021 | 0.85 | NPC1 (0.39) | KMT2ATP53LMNATHRBSMN1; SMN2 | |
| SCHEMBL6992582 | 0.83 | TRPV1 (0.36) | — | |
| SCHEMBL6998484 | 0.82 | TRPV1 (0.39) | — | |
| SCHEMBL6300424 | 0.82 | IDO1 (0.44) | IDO1KMT2ASMN1; SMN2 | |
| SCHEMBL6988745 | 0.82 | CTSK (0.35) | KMT2ALMNASMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358176-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057246-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |