Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 18/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.64 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8928388 | 0.93 | PTAFR (0.73) | PTAFROPRK1PDE4DGABRA1GABRG2 | |
| SCHEMBL11509934 | 0.82 | PTAFR (0.79) | PTAFROPRK1PDE4DGABRA1GABRG2 | |
| SCHEMBL8928433 | 0.82 | PTAFR (0.79) | PTAFROPRK1PDE4DGABRA1GABRG2 | |
| SCHEMBL9379295 | 0.80 | PTAFR (1.00) | PTAFROPRK1PDE4DGABRA1GABRG2 | |
| Brotizolam SCHEMBL44067 | 0.80 | PTAFR (1.00) | PTAFROPRK1PDE4DGABRA1GABRG2 | |
| Brotizolam SCHEMBL29396298 | 0.80 | PTAFR (1.00) | PTAFROPRK1PDE4DGABRA1GABRG2 | |
| Etizolam SCHEMBL42920 | 0.79 | OPRK1 (1.00) | PTAFROPRK1PDE4D | |
| SCHEMBL8928754 | 0.79 | PTAFR (0.73) | PTAFROPRK1PDE4DGABRA1GABRG2 | |
| Etizolam SCHEMBL30665015 | 0.79 | OPRK1 (1.00) | PTAFROPRK1PDE4D | |
| SCHEMBL9379443 | 0.79 | PTAFR (1.00) | PTAFROPRK1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0606103-B1 | Thieno 3.2-f 1,2,4 triazolo 4,3-a 1,4 -diazepine derivatives as PAF antagonists | EISAI CO LTD (JP) | 2003-03-12 | — | — | EP | disclosed |
| US-5482937-A | ANTIALLERGENS AND PLATELET ACTIVATING FACTOR FOR TREATMENT OF INFLAMMATION | EISAI CO., LTD. (JP) | 1996-01-09 | — | — | US | disclosed |
| US-5468740-A | Anti-platelet activating factor activity; antiallergens, antiasthmatics | EISAI CO., LTD. (JP) | 1995-11-21 | — | — | US | disclosed |
| EP-0677524-A1 | Thieno[3,2-F][1,2,4]triazolo[4,3-A][1,4]diazepine derivatives as PAF antagonists | Eisai Co., Ltd. (JP) | 1995-10-18 | — | — | EP | disclosed |
| US-5438045-A | An 3-acetyl-6-phenyl-2,3,4,5-tetrahydro-8h-pyrido(4'3':4,5)-thieno(3,2 -f)(1,2,4)triazolo(4,3-a)(1,4)diazepine derivative; antiallergens; asthma; antiplatelet activating factor activity | EISAI CO., LTD. (JP) | 1995-08-01 | — | — | US | disclosed |
| EP-0606103-A1 | Thieno 3.2-f 1,2,4 triazolo 4,3-a 1,4 -diazepine derivatives as PAF antagonists | Eisai Co., Ltd. (JP) | 1994-07-13 | — | — | EP | disclosed |
| US-5221671-A | Antiallergens, bronchodilator agents | EISAI CO., LTD. (JP) | 1993-06-22 | — | — | US | disclosed |
| EP-0367110-A1 | 1,4-diazepine derivative and its pharmaceutical use | Eisai Co., Ltd. (JP) | 1990-05-09 | — | — | EP | disclosed |