Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994825 | 0.76 | ALDH1A1 (0.41) | LMNACYP1A2CYP2C9NPSR1KDM4E | |
| SCHEMBL6998461 | 0.72 | KDM4E (0.49) | LMNASMN1; SMN2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL1092493 | 0.72 | ALDH1A1 (0.52) | LMNASMN1; SMN2NPSR1KDM4EALDH1A1 | |
| SCHEMBL13034152 | 0.66 | SMN1; SMN2 (0.57) | LMNASMN1; SMN2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL26741264 | 0.66 | ALDH1A1 (0.44) | LMNASMN1; SMN2KDM4EALDH1A1AKR1B1 | |
| SCHEMBL4647196 | 0.65 | ALDH1A1 (0.61) | LMNASMN1; SMN2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL29853925 | 0.65 | ALDH1A1 (0.61) | LMNASMN1; SMN2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL605494 | 0.64 | ALDH1A1 (0.53) | LMNASMN1; SMN2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL30025953 | 0.64 | ALDH1A1 (0.42) | LMNASMN1; SMN2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6837449 | 0.62 | ALDH1A1 (0.47) | KDM4EALDH1A1ELANEGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003724-B1 | SUBSTITUTED QUINOLINE DERIVATIVES WITH ANTIVIRAL ACTION | AVENTIS PHARMA GMBH (DE) | 2003-02-12 | — | — | EP | disclosed |
| EP-1003724-A1 | SUBSTITUTED QUINOLINE DERIVATIVES WITH ANTIVIRAL ACTION | Aventis Pharma Deutschland GmbH (DE) | 2000-05-31 | — | — | EP | disclosed |
| WO-1997037977-A1 | SUBSTITUTED QUINOLINE DERIVATIVES WITH ANTIVIRAL ACTION | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-10-16 | — | — | WO | disclosed |