Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002087 | 0.90 | SLC6A3 (0.79) | SLC6A3KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL7001985 | 0.82 | KMT2A (0.79) | SLC6A3KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL4194116 | 0.82 | SLC6A3 (1.00) | SLC6A3KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL7001626 | 0.82 | KMT2A (0.70) | SLC6A3KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL6998081 | 0.81 | KMT2A (0.77) | SLC6A3KMT2AALDH1A1MAPTLMNA | |
| Flazalone SCHEMBL43716 | 0.79 | KMT2A (1.00) | SLC6A3KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL7003749 | 0.79 | KMT2A (0.77) | SLC6A3KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL6997233 | 0.79 | KMT2A (1.00) | SLC6A3KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL7001736 | 0.77 | KMT2A (0.73) | SLC6A3KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL7001994 | 0.76 | KMT2A (0.68) | SLC6A3KMT2AALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242080-A4 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | UNIV GEORGETOWN (US) | 2003-01-22 | — | — | EP | claimed |
| EP-1242080-A1 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | GEORGETOWN UNIVERSITY (US) | 2002-09-25 | — | — | EP | claimed |
| WO-2001022964-A1 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | GEORGETOWN UNIVERSITY (US) | 2001-04-05 | — | — | WO | claimed |
| EP-1242080-A4 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | UNIV GEORGETOWN (US) | 2003-01-22 | — | — | EP | disclosed |
| EP-1242080-A1 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | GEORGETOWN UNIVERSITY (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001022964-A1 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | GEORGETOWN UNIVERSITY (US) | 2001-04-05 | — | — | WO | disclosed |