Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.35 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990239 | 0.82 | ALDH1A1 (0.42) | ALDH1A1AKR1C3AKR1C2SMN1; SMN2KDM4E | |
| SCHEMBL6995106 | 0.81 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2KDM4EMEN1NPC1 | |
| SCHEMBL31211725 | 0.78 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2KDM4EMEN1POLB | |
| SCHEMBL31211692 | 0.78 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2KDM4EMEN1POLB | |
| SCHEMBL13681886 | 0.77 | RXFP1 (0.37) | ALDH1A1KDM4EMEN1NPC1POLB | |
| SCHEMBL13681867 | 0.77 | RXFP1 (0.41) | ALDH1A1SMN1; SMN2KDM4EMEN1NPC1 | |
| SCHEMBL4885673 | 0.76 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2KDM4EMEN1NPC1 | |
| SCHEMBL23609615 | 0.76 | SMN1; SMN2 (0.43) | ALDH1A1SMN1; SMN2KDM4EMEN1NPC1 | |
| SCHEMBL23609610 | 0.76 | FABP4 (0.48) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL5904052 | 0.74 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2KDM4EMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309575-A1 | BIPHENYL DERIVATIVES AND THEIR USE AS PPAR-GAMMA RECEPTOR ACTIVATORS | Galderma Research & Development (FR) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002012210-A9 | BIPHENYL DERIVATIVES AND THEIR USE AS PPAR-GAMMA RECEPTOR ACTIVATORS | GALDERMA RES & DEV (FR) | 2002-04-18 | — | — | WO | disclosed |
| WO-2002012210-A1 | BIPHENYL DERIVATIVES AND THEIR USE AS PPAR-GAMMA RECEPTOR ACTIVATORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2002-02-14 | — | — | WO | disclosed |