Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | NAT1 | P18440 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995100 | 0.82 | ALDH1A1 (0.42) | ALDH1A1CYP2A6MEN1KMT2AKDM4E | |
| SCHEMBL4885673 | 0.80 | ALDH1A1 (0.43) | ALDH1A1CYP2A6MEN1KMT2AKDM4E | |
| SCHEMBL6990245 | 0.79 | DRD1 (0.47) | ALDH1A1CYP2A6MEN1KMT2AKDM4E | |
| SCHEMBL35967 | 0.77 | ALDH1A1 (0.48) | ALDH1A1CYP2A6MEN1KMT2AKDM4E | |
| SCHEMBL11837965 | 0.77 | ESR2 (0.53) | ALDH1A1CYP2A6MEN1KMT2AKDM4E | |
| SCHEMBL257774 | 0.77 | MEN1 (0.46) | ALDH1A1CYP2A6MEN1KMT2AKDM4E | |
| SCHEMBL29681880 | 0.75 | ALDH1A1 (0.42) | ALDH1A1CYP2A6KDM4ETRIM24TRIM33 | |
| SCHEMBL7273589 | 0.75 | ALDH1A1 (0.42) | ALDH1A1CYP2A6KDM4ETRIM24TRIM33 | |
| SCHEMBL3933848 | 0.74 | KDM4E (0.57) | ALDH1A1CYP2A6MEN1KMT2AKDM4E | |
| SCHEMBL5490742 | 0.74 | ALDH1A1 (0.50) | ALDH1A1CYP2A6MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101296897-A | PPAR-modulating biaromatic compounds | GALDERMA RES & DEV (FR) | 2008-10-29 | — | — | CN | disclosed |
| EP-1309575-A1 | BIPHENYL DERIVATIVES AND THEIR USE AS PPAR-GAMMA RECEPTOR ACTIVATORS | Galderma Research & Development (FR) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002012210-A9 | BIPHENYL DERIVATIVES AND THEIR USE AS PPAR-GAMMA RECEPTOR ACTIVATORS | GALDERMA RES & DEV (FR) | 2002-04-18 | — | — | WO | disclosed |
| WO-2002012210-A1 | BIPHENYL DERIVATIVES AND THEIR USE AS PPAR-GAMMA RECEPTOR ACTIVATORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2002-02-14 | — | — | WO | disclosed |