Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.46 |
| ▸ | MMP13 | P45452 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995243 | 0.88 | MMP1 (0.46) | MMP1MMP13ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL7001941 | 0.88 | MMP1 (0.56) | MMP1MMP13ALDH1A1KMT2AHPGD | |
| SCHEMBL6998853 | 0.88 | MMP1 (0.56) | MMP1MMP13ALDH1A1KMT2AHPGD | |
| SCHEMBL7993451 | 0.81 | MMP1 (0.45) | MMP1MMP13ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL2409029 | 0.80 | MMP1 (0.50) | MMP1MMP13ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL7993340 | 0.76 | MMP1 (0.56) | MMP1MMP13ALDH1A1L3MBTL1MMP2 | |
| SCHEMBL6993318 | 0.73 | S1PR5 (0.41) | MMP1MMP13ALDH1A1S1PR5FFAR1 | |
| SCHEMBL6995225 | 0.72 | MMP1 (0.42) | MMP1MMP13ALDH1A1L3MBTL1GAA | |
| SCHEMBL6995230 | 0.72 | MMP1 (0.42) | MMP1MMP13ALDH1A1L3MBTL1GAA | |
| SCHEMBL7993343 | 0.71 | ALDH1A1 (0.33) | MMP1MMP13ALDH1A1L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070069-B1 | BICYCLIC HYDROXAMIC ACID DERIVATIVES | PFIZER PROD INC (US) | 2003-07-16 | — | — | EP | disclosed |
| US-6110964-A | FOR TREATING ARTHRITIS, INFLAMMATORY BOWEL DISEASE, CROHN'S DISEASE, EMPHYSEMA, ACUTE RESPIRATORY DISTRESS SYNDROME, ASTHMA CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ALZHEIMER'S DISEASE, ORGAN TRANSPLANT TOXICITY, CACHEXIA, CANCER | PFIZER INC. (US) | 2000-08-29 | — | — | US | disclosed |