Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HPGDS | O60760 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990226 | 0.86 | BRD4 (0.43) | BRD4KDRSMN1; SMN2KDM4E | |
| SCHEMBL6998152 | 0.78 | KDM4E (0.44) | BRD4KDM4EHPGDALDH1A1GAA | |
| SCHEMBL72613 | 0.72 | AR (0.43) | SMN1; SMN2HPGDCYP3A4CYP2C19 | |
| SCHEMBL6998491 | 0.72 | KDR (0.35) | BRD4KDRKDM4EHPGDALDH1A1 | |
| SCHEMBL6995905 | 0.68 | PTGS2 (0.46) | KDM4EHPGDMEN1ALDH1A1CYP1A2 | |
| SCHEMBL7093334 | 0.68 | KDM4E (0.46) | SMN1; SMN2KDM4EHPGDALDH1A1GAA | |
| SCHEMBL7567903 | 0.67 | PTGS2 (0.34) | SMN1; SMN2HPGDHPGDS | |
| SCHEMBL10892833 | 0.67 | KDM4E (0.56) | KDM4ECYP3A4 | |
| SCHEMBL7093332 | 0.66 | HSD17B10 (0.44) | SMN1; SMN2KDM4EHPGDALDH1A1CYP1A2 | |
| SCHEMBL10472855 | 0.65 | HSD17B1 (0.47) | SMN1; SMN2KDM4EHPGDMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921119-B1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-07-02 | — | — | EP | disclosed |
| US-6114360-A | Pyrrole compounds | ADIR ET COMPAGNIE (FR) | 2000-09-05 | — | — | US | disclosed |
| US-6063804-A | Pyrrole compounds | ADIR ET COMPAGNIE (FR) | 2000-05-16 | — | — | US | disclosed |
| EP-0921119-A1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-06-09 | — | — | EP | disclosed |