Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998152 | 0.84 | KDM4E (0.44) | KDM4EALDH1A1HPGDGAA | |
| SCHEMBL6990217 | 0.83 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL6998482 | 0.75 | CDKN1A (0.44) | PTGS2KDM4EHPGDPTGS1NISCH | |
| SCHEMBL403028 | 0.73 | PTGS2 (0.63) | PTGS2GSK3BALDH1A1PTGS1MEN1 | |
| SCHEMBL17283465 | 0.73 | PTGS2 (0.63) | PTGS2GSK3BALDH1A1PTGS1MEN1 | |
| Hydrogen Sulfide SCHEMBL19086306 | 0.71 | PTGS2 (0.61) | PTGS2GSK3BALDH1A1PTGS1MEN1 | |
| SCHEMBL7567894 | 0.69 | PTGS2 (0.53) | PTGS2GSK3BKDM4EALDH1A1HPGD | |
| SCHEMBL29158890 | 0.68 | PTGS2 (0.41) | PTGS2GSK3BKDM4EMEN1KMT2A | |
| SCHEMBL6995912 | 0.68 | BRD4 (0.34) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL1131081 | 0.68 | MAPK13 (0.67) | GSK3BKDM4EALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921119-B1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-07-02 | — | — | EP | disclosed |
| US-6114360-A | Pyrrole compounds | ADIR ET COMPAGNIE (FR) | 2000-09-05 | — | — | US | disclosed |
| US-6063804-A | Pyrrole compounds | ADIR ET COMPAGNIE (FR) | 2000-05-16 | — | — | US | disclosed |
| EP-0921119-A1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-06-09 | — | — | EP | disclosed |