Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 11/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.45 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997253 | 0.88 | ADORA2A (0.48) | ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL8563585 | 0.82 | ADORA2B (0.54) | MEN1CYP1A2CYP3A4CYP2C19KMT2A | |
| SCHEMBL7001583 | 0.76 | ADORA2A (0.49) | MEN1CYP1A2CYP3A4CYP2C19KMT2A | |
| SCHEMBL8872400 | 0.72 | ADORA2B (0.69) | MEN1CYP1A2CYP3A4CYP2C19KMT2A | |
| SCHEMBL1063544 | 0.68 | SIRT1 (0.68) | MEN1LMNACYP1A2CYP3A4CYP2C19 | |
| Furafylline SCHEMBL191214 | 0.66 | MEN1 (1.00) | MEN1LMNACYP1A1CYP1A2CYP3A4 | |
| SCHEMBL25539381 | 0.66 | ADORA2A (0.58) | ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL9585428 | 0.66 | ADORA2B (0.57) | MEN1CYP1A2CYP3A4CYP2C19KMT2A | |
| SCHEMBL6999142 | 0.65 | SIRT1 (0.46) | MEN1LMNACYP1A1CYP1A2CYP3A4 | |
| SCHEMBL1720432 | 0.65 | ADORA2A (0.51) | MEN1CYP1A2CYP3A4CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087973-B1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-01-08 | — | — | EP | claimed |
| EP-1087973-A1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | Boehringer Ingelheim Pharma KG (DE) | 2001-04-04 | — | — | EP | claimed |
| WO-1999065912-A1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-12-23 | — | — | WO | claimed |
| EP-1087973-B1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-01-08 | — | — | EP | disclosed |