Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6300590 | 0.92 | ESRRG (0.36) | MEN1KMT2APOLBHTT | |
| SCHEMBL6993579 | 0.90 | LMNA (0.38) | MEN1KMT2AEPHX2 | |
| SCHEMBL7204140 | 0.88 | KMT2A (0.41) | NAMPTKMT2A | |
| SCHEMBL6985955 | 0.80 | NAMPT (0.37) | DPP4DHODHGCGRNAMPTMEN1 | |
| SCHEMBL6294857 | 0.77 | CTSL (0.47) | — | |
| SCHEMBL6997966 | 0.77 | MEN1 (0.34) | DPP4GCGRMEN1KMT2APOLB | |
| SCHEMBL6988551 | 0.76 | TP53 (0.35) | DPP4GCGRMEN1KMT2APOLB | |
| SCHEMBL6990244 | 0.75 | TP53 (0.38) | GCGRMEN1KMT2APOLBCCR2 | |
| SCHEMBL6994214 | 0.74 | MEN1 (0.36) | DPP4MEN1KMT2APOLBCCR2 | |
| SCHEMBL6294790 | 0.73 | CTSL (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358176-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057246-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |