Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993579 | 0.90 | LMNA (0.38) | KMT2AHPGDNPC1SMN1; SMN2HDAC3 | |
| SCHEMBL6300590 | 0.89 | ESRRG (0.36) | KMT2AHPGDNPC1SMN1; SMN2MAPT | |
| SCHEMBL6996553 | 0.88 | DPP4 (0.37) | KMT2ANAMPT | |
| SCHEMBL6985259 | 0.80 | HDAC1 (0.40) | KMT2AHPGDNPC1SMN1; SMN2HDAC1 | |
| SCHEMBL6989694 | 0.78 | KMT2A (0.40) | KMT2AHPGDNPC1SMN1; SMN2HDAC1 | |
| SCHEMBL6698003 | 0.77 | CTSL (0.45) | KMT2AHPGDNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6988021 | 0.76 | NPC1 (0.39) | KMT2AHPGDNPC1SMN1; SMN2MAPT | |
| SCHEMBL6993839 | 0.76 | HTR1A (0.39) | KMT2AHPGDNPC1SMN1; SMN2HDAC1 | |
| SCHEMBL6294822 | 0.75 | CTSB (0.49) | KMT2AHPGDNPC1SMN1; SMN2HDAC1 | |
| SCHEMBL6986470 | 0.74 | HPGD (0.38) | KMT2AHPGDNPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358176-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057246-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |