Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6300590 | 0.90 | ESRRG (0.36) | LMNAHPGDRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL7204140 | 0.90 | KMT2A (0.41) | HPGDSMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL6996553 | 0.90 | DPP4 (0.37) | MEN1KMT2AEPHX2 | |
| SCHEMBL6985875 | 0.80 | LMNA (0.40) | LMNAHPGDRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6988745 | 0.80 | CTSK (0.35) | LMNAHPGDRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6994067 | 0.78 | RAB9A (0.41) | LMNARAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL6699225 | 0.76 | CTSK (0.53) | CTSK | |
| SCHEMBL6993081 | 0.76 | CTSK (0.35) | LMNARAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL6992764 | 0.76 | HPGD (0.39) | LMNAHPGDRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6295603 | 0.75 | TACR2 (0.40) | CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358176-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057246-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |