Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | LIPE | Q05469 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003209 | 0.86 | APP (0.47) | APPLMNACYP2C19CYP1A2PTGS1 | |
| SCHEMBL183414 | 0.84 | MAPT (0.48) | LMNACYP2C19CYP1A2PTGS1SLC6A2 | |
| SCHEMBL1616224 | 0.81 | MAPT (0.55) | CYP2C19LIPEMAPTTDP1L3MBTL1 | |
| SCHEMBL7243289 | 0.80 | HTR1A (0.47) | LMNALIPEMAPTTDP1L3MBTL1 | |
| SCHEMBL1446254 | 0.79 | HPGD (0.46) | HDAC6LIPEMAPTTDP1L3MBTL1 | |
| SCHEMBL11513558 | 0.79 | RAB9A (0.46) | LIPEMAPTTDP1L3MBTL1MAPK1 | |
| SCHEMBL1099955 | 0.79 | MAPT (0.44) | SLC6A2SLC6A3LIPEMAPTTDP1 | |
| SCHEMBL5315646 | 0.79 | APP (0.47) | APPLIPEMAPTTDP1L3MBTL1 | |
| SCHEMBL339374 | 0.78 | HTR1A (0.53) | APPCYP1A2LIPEMAPTTDP1 | |
| SCHEMBL182637 | 0.78 | HTR1A (0.53) | APPLMNACYP1A2HDAC6LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113784713-A | Leukotriene synthesis inhibitors | 纳吉斯制药股份有限公司 | 2021-12-10 | — | — | CN | disclosed |
| CN-1117093-C | Pyrazolo [1, 5-a ] pyrimidine derivatives, their use and compositions | OTSUKA PHARMA CO LTD (JP) | 2003-08-06 | — | — | CN | disclosed |
| EP-1081149-B1 | PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6372749-B1 | PHARMACOLOGICAL EFFECTS SUCH AS ANALGESIC ACTION, INHIBITORY EFFECT ON NITROGEN MONOXIDE SYNTHETASE AND THE LIKE AND ARE USEFUL AS ANALGESICS. | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2002-04-16 | — | — | US | disclosed |
| CN-1299362-A | Pyrazolo [1,5-a] pyrimidine derivatives | OTSUKA PHARMA CO LTD (JP) | 2001-06-13 | — | — | CN | disclosed |
| EP-1081149-A1 | PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2001-03-07 | — | — | EP | disclosed |
| CN-1227555-A | Cytokine production inhibitors triazepine compounds, and intermediates thereof | JAPAN TOBACCO INC (JP) | 1999-09-01 | — | — | CN | disclosed |
| EP-0934940-A1 | CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF | Japan Tobacco Inc. (JP) | 1999-08-11 | — | — | EP | disclosed |
| US-5807850-A | Therapeutic agent for osteoporosis and triazepine compound | JAPAN TOBACCO, INC. (JP) | 1998-09-15 | — | — | US | disclosed |
| CN-1171788-A | Therapeutic agent for osteoporosis and triaza * compound | JAPAN TOBACCO INC (JP) | 1998-01-28 | — | — | CN | disclosed |
| CN-1159325-A | Co-therapy for Parkinson's syndrome | PFIZER (US) | 1997-09-17 | — | — | CN | disclosed |
| EP-0792880-A1 | OSTEOPOROSIS REMEDY AND TRIAZEPINE COMPOUND | Japan Tobacco Inc. (JP) | 1997-09-03 | — | — | EP | disclosed |