Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 5/20 | 0.45 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.45 |
| ▸ | TOP2A | P11388 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | PRKACG | P22612 | 1/20 | 0.41 |
| ▸ | PRKACB | P22694 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | MYLK | Q15746 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6864479 | 0.90 | MPO (0.45) | MPOHAVCR2TOP2ACDK4PRKACA | |
| SCHEMBL6860285 | 0.90 | PRKACA (0.47) | MPOHAVCR2TOP2ACDK4PRKACA | |
| SCHEMBL6866883 | 0.85 | MPO (0.38) | MPOHAVCR2TOP2ACDK4PRKACA | |
| SCHEMBL6997570 | 0.78 | SIRT2 (0.49) | HAVCR2ALDH1A1KMT2ADRD2DRD4 | |
| SCHEMBL25333651 | 0.67 | MPO (0.82) | MPOHAVCR2XDHALDH1A1KMT2A | |
| SCHEMBL4419395 | 0.67 | MEN1 (0.63) | MPOHAVCR2ALDH1A1KMT2AMAPT | |
| SCHEMBL11736951 | 0.66 | CDK4 (0.58) | MPOHAVCR2TOP2ACDK4PRKACA | |
| SCHEMBL11735517 | 0.66 | CDK4 (0.58) | MPOHAVCR2TOP2ACDK4PRKACA | |
| Hydrochloric Acid SCHEMBL9725349 | 0.66 | RAB9A (0.64) | MPOHAVCR2ALDH1A1KMT2AMAPT | |
| SCHEMBL7198661 | 0.65 | GSK3B (0.58) | HAVCR2ALDH1A1KMT2AHTR6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109785-B1 | INDOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF MALIGNANT AND OTHER DISEASES CAUSED BY PATHOLOGICAL CELL PROLIFERATION | ZENTARIS AG (DE) | 2003-01-02 | — | — | EP | disclosed |