Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 4/20 | 0.47 |
| ▸ | PRKACG | P22612 | 4/20 | 0.47 |
| ▸ | PRKACB | P22694 | 4/20 | 0.47 |
| ▸ | CDK4 | P11802 | 2/20 | 0.47 |
| ▸ | CCND1 | P24385 | 2/20 | 0.47 |
| ▸ | MPO | P05164 | 4/20 | 0.45 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 3/20 | 0.42 |
| ▸ | PRKCA | P17252 | 8/20 | 0.42 |
| ▸ | PRKCB | P05771 | 7/20 | 0.42 |
| ▸ | MYLK | Q15746 | 2/20 | 0.42 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | PRKCH | P24723 | 5/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.41 |
| ▸ | PRKCG | P05129 | 4/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.41 |
| ▸ | PRKCI | P41743 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6864479 | 0.90 | MPO (0.45) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL6997136 | 0.90 | MPO (0.45) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL6866883 | 0.81 | MPO (0.38) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL6867398 | 0.74 | CDK4 (0.49) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL11736951 | 0.66 | CDK4 (0.58) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL11735517 | 0.66 | CDK4 (0.58) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL6997570 | 0.66 | SIRT2 (0.49) | HAVCR2MEN1GSK3BKMT2ACYP1A2 | |
| SCHEMBL10704467 | 0.65 | ALDH1A1 (0.59) | MPOHAVCR2TOP2ACYP1A2MAPT | |
| SCHEMBL8112983 | 0.65 | MYLK (0.71) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL6871069 | 0.65 | ROCK2 (0.58) | CDK4CCND1PRKCBMEN1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6812243-B2 | AS TYROSINE KINASE INHIBITORS; FOR THERARPY OF TUMORS, ARTERIOSCLEROSIS, RESTENOSIS AFTER BALLOON ANGIOPLASTY, ARTHRITIS AND FIBROTIC DISEASES | ZENTARIS AG (DE) | 2004-11-02 | — | — | US | disclosed |
| US-20030008898-A1 | Indole derivatives and their use for the treatment of malignant and other diseases based on pathological proliferation | ZENTARIS AG (DE) | 2003-01-09 | — | — | US | disclosed |
| EP-1109785-B1 | INDOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF MALIGNANT AND OTHER DISEASES CAUSED BY PATHOLOGICAL CELL PROLIFERATION | ZENTARIS AG (DE) | 2003-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030008898-A1 | Indole derivatives and their use for the treatment of malignant and other diseases based on pathological proliferation | MKI67, IDO1, CCNI | PRKACA 708/4885PRKACG 903/4885PRKACB 1062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.