Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005795 | 0.79 | PTGS2 (0.39) | RAB9APTGS2PTGS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7001813 | 0.79 | PTGS2 (0.44) | PTGS2PTGS1 | |
| SCHEMBL6994135 | 0.78 | PTGS2 (0.43) | PTGS2PTGS1 | |
| SCHEMBL3333548 | 0.78 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2LMNAKDM4EMAPT | |
| SCHEMBL16263830 | 0.71 | KDM4E (0.40) | ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL6993536 | 0.71 | SIGMAR1 (0.49) | RAB9ANPC1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL7002291 | 0.70 | SIGMAR1 (0.48) | RAB9ANPC1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL6997064 | 0.67 | PTGS2 (0.54) | RAB9APTGS2PTGS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6997168 | 0.64 | PTGS2 (0.54) | RAB9APTGS2PTGS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14317670 | 0.62 | SLC6A4 (0.54) | RAB9ANPC1SLC6A4SLC6A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | disclosed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | disclosed |
| EP-1109799-A1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORPORATION (KR) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000061571-A1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORPORATION (KR) | 2000-10-19 | — | — | WO | disclosed |