SCHEMBL6997419

SCHEMBL6997419

COc1cc(C(=O)NC(C)(C)C)ccc1C

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAS1R3 Q7RTX0 1/20 0.52
TAS1R1 Q7RTX1 1/20 0.52
MAPT P10636 3/20 0.50
CYP1A2 P05177 2/20 0.50
CYP3A4 P08684 2/20 0.50
CYP2C9 P11712 2/20 0.50
CYP2C19 P33261 2/20 0.50
MEN1 O00255 1/20 0.50
ALDH1A1 P00352 1/20 0.50
ALOX12 P18054 1/20 0.50
RAB9A P51151 1/20 0.50
KMT2A Q03164 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
PKM P14618 1/20 0.49
PTPN7 P35236 1/20 0.48
DUSP3 P51452 1/20 0.48
ALOX15 P16050 1/20 0.47
MAPK1 P28482 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
IMPDH2 P12268 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23224211 0.87 IMPDH2 (0.60) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL13701787 0.83 ANO1 (0.53) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL1933083 0.83 ALDH1A1 (0.59) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL6995544 0.83 ALDH1A1 (0.49) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL14880129 0.81 HDAC1 (0.59) TAS1R3TAS1R1PKM
SCHEMBL9103250 0.81 TAS1R3 (0.56) TAS1R3TAS1R1MAPTCYP1A2CYP3A4
SCHEMBL14867646 0.81 KMT2A (0.51) TAS1R3TAS1R1MAPTMEN1ALDH1A1
SCHEMBL13947173 0.80 TAS1R3 (0.55) TAS1R3TAS1R1MAPTCYP1A2CYP3A4
SCHEMBL12937578 0.80 TAS1R3 (0.58) TAS1R3TAS1R1MAPTCYP1A2CYP3A4
SCHEMBL13701797 0.79 RAB9A (0.61) TAS1R3TAS1R1MAPTCYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0950047-B1 INDOLIN-2-ONE DERIVATIVES, METHOD FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SANOFI SYNTHELABO (FR) 2003-10-15 EP disclosed
EP-0873309-B1 3-SPIRO-INDOLIN-2-ONE DERIVATIVES AS VASOPRESSIN AND/OR OXYTOCIN RECEPTOR LIGANDS SANOFI SYNTHELABO (FR) 2002-12-18 EP disclosed
US-6090818-A CARDIOVASCULAR DISORDERS; ANTISECRETORY AGENTS; OXYTOCIN, VASOPRESSIN ANTAGONIST SANOFI-SYNTHELABO (FR) 2000-07-18 US disclosed
US-6046341-A AN ACTIVE DRUG HAVING AFFINITY FOR VASOPRESSIN AND/OR OXYTOCIN RECEPTORS SANOFI-SYNTHELABO (FR) 2000-04-04 US disclosed
US-5994350-A CARDIOVASCULAR DISORDERS; CENTRAL NERVOUS SYSTEM DISORDERS; GASTROINTESTINAL DISORDERS; RESPIRATORY SYSTEM DISORDERS SANOFI-SYNTHELABO (FR) 1999-11-30 US disclosed
EP-0950047-A1 INDOLIN-2-ONE DERIVATIVES, METHOD FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SANOFI-SYNTHELABO (FR) 1999-10-20 EP disclosed
EP-0873309-A1 3-SPIRO-INDOLIN-2-ONE DERIVATIVES AS VASOPRESSIN AND/OR OXYTOCIN RECEPTOR LIGANDS SANOFI (FR) 1998-10-28 EP disclosed
WO-1998025901-A1 INDOLIN-2-ONE DERIVATIVES, METHOD FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SANOFI (FR) 1998-06-18 WO disclosed
WO-1997015556-A1 3-SPIRO-INDOLIN-2-ONE DERIVATIVES AS VASOPRESSIN AND/OR OXYTOCIN RECEPTOR LIGANDS SANOFI (FR) 1997-05-01 WO disclosed