Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.44 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KHK | P50053 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2610311 | 0.79 | MGLL (0.57) | HPGDMGLLPLA2G10HSD17B10SMO | |
| SCHEMBL1667310 | 0.77 | PLA2G10 (0.55) | HPGDMGLLPLA2G10SMOKHK | |
| SCHEMBL9986667 | 0.76 | SMO (0.49) | HPGDMGLLPLA2G10SMOKHK | |
| SCHEMBL30040852 | 0.76 | SMO (0.49) | HPGDMGLLPLA2G10SMOKHK | |
| SCHEMBL30204361 | 0.76 | ALKBH2 (0.51) | MGLLPLA2G10EGLN1KDM4E | |
| SCHEMBL27576003 | 0.76 | MGLL (0.44) | HPGDMGLLPLA2G10HSD17B10SMO | |
| SCHEMBL5563702 | 0.75 | CYP11B1 (0.39) | KDM4E | |
| SCHEMBL5780198 | 0.74 | CYP11B2 (0.47) | KDM4E | |
| SCHEMBL30864253 | 0.73 | CYP11B2 (0.63) | HPGDMGLLPLA2G10HSD17B10SMO | |
| SCHEMBL30864308 | 0.72 | HCAR2 (0.45) | HPGDMGLLPLA2G10HSD17B10SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313711-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002010137-A9 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARM INC (US) | 2003-02-06 | — | — | WO | disclosed |
| WO-2002010137-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2002-02-07 | — | — | WO | disclosed |