Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | AHR | P35869 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8126943 | 0.70 | KDM4E (0.41) | SMN1; SMN2MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL22095514 | 0.68 | LMNA (0.40) | SMN1; SMN2MAPTLMNAALDH1A1AHR | |
| SCHEMBL3677538 | 0.67 | KDM4E (0.41) | SMN1; SMN2MAPTALDH1A1KDM4EMAPK1 | |
| SCHEMBL3679921 | 0.65 | DGAT1 (0.39) | SMN1; SMN2MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL362526 | 0.65 | KMT2A (0.40) | SMN1; SMN2MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL4822430 | 0.63 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL8912927 | 0.61 | KDM4E (0.45) | SMN1; SMN2MAPTALDH1A1KDM4EMAPK1 | |
| SCHEMBL28079765 | 0.61 | MAPT (0.49) | SMN1; SMN2MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL25276442 | 0.61 | GAA (0.39) | ALDH1A1KDM4EMAPK1GAACYP2C19 | |
| SCHEMBL2979196 | 0.61 | ALDH1A1 (0.36) | SMN1; SMN2MAPTALDH1A1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307200-A2 | SUBSTITUTED-TRIAZOLOPYRIMIDINES AS ANTICANCER AGENTS | Wyeth (US) | 2003-05-07 | — | — | EP | claimed |
| WO-2002002563-A2 | SUBSTITUTED-TRIAZOLOPYRIMIDINES AS ANTICANCER AGENTS | WYETH (US) | 2002-01-10 | — | — | WO | claimed |