Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995318 | 0.83 | GABRG2 (0.33) | GABRG2GABRB3GABRA5PDE2APDE10A | |
| SCHEMBL7003157 | 0.66 | GABRA1 (0.39) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL7001199 | 0.65 | HPGD (0.36) | GABRG2GABRB3GABRA5MAPTGABRA1 | |
| SCHEMBL7005680 | 0.64 | LRRK2 (0.34) | GABRG2GABRB3GABRA3 | |
| SCHEMBL7003645 | 0.64 | LRRK2 (0.32) | GABRG2GABRB3GABRA5 | |
| SCHEMBL6998632 | 0.63 | GABRG2 (0.74) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL7003397 | 0.61 | GABRA1 (0.39) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL27447606 | 0.60 | ALDH1A1 (0.39) | PDE2APDE10AMAPT | |
| SCHEMBL18415097 | 0.60 | TYK2 (0.41) | GABRG2GABRB3GABRA1GABRA3TYK2 | |
| SCHEMBL6994216 | 0.60 | GABRA1 (0.37) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | claimed |