Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001199 | 0.87 | HPGD (0.36) | LRRK2HSD17B10NPC1GABRG2GABRB3 | |
| SCHEMBL7003645 | 0.85 | LRRK2 (0.32) | LRRK2GABRG2GABRB3 | |
| SCHEMBL7002972 | 0.70 | HPGD (0.36) | LRRK2HSD17B10NPC1RAB9AGABRG2 | |
| SCHEMBL7001541 | 0.69 | LRRK2 (0.32) | LRRK2GABRG2GABRB3 | |
| SCHEMBL7002883 | 0.68 | GABRA1 (0.32) | LRRK2GABRG2GABRB3GABRA3 | |
| SCHEMBL7002461 | 0.67 | GABRA1 (0.33) | LRRK2GABRG2GABRB3GABRA3 | |
| SCHEMBL2656994 | 0.66 | GABRG2 (0.65) | GABRG2GABRB3GABRA3 | |
| SCHEMBL7002447 | 0.64 | GABRA1 (0.35) | LRRK2NPC1RAB9AGABRG2GABRB3 | |
| SCHEMBL7482590 | 0.63 | GABRA1 (0.52) | GABRG2GABRB3GABRA3 | |
| SCHEMBL7208541 | 0.62 | GABRG2 (0.46) | GABRG2GABRB3GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | claimed |