SCHEMBL6999632

SCHEMBL6999632

Cc1sc(NC(=O)c2ccc(Cl)cc2Cl)c(C(N)=O)c1C

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 8/20 0.62
MAPT P10636 7/20 0.62
NPC1 O15118 7/20 0.62
ALDH1A1 P00352 5/20 0.62
SMN1; SMN2 Q16637 4/20 0.62
KDM4E B2RXH2 3/20 0.62
TP53 P04637 2/20 0.62
NFKB1 P19838 1/20 0.62
MAPK1 P28482 1/20 0.62
CASP1 P29466 1/20 0.62
CASP7 P55210 1/20 0.62
NFKB2 Q00653 1/20 0.62
RELA Q04206 1/20 0.62
NPSR1 Q6W5P4 1/20 0.62
HPGD P15428 3/20 0.57
LMNA P02545 3/20 0.57
MCL1 Q07820 1/20 0.57
GRIN2C Q14957 1/20 0.55
MAPK10 P53779 1/20 0.55
HSD17B10 Q99714 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7673789 0.90 ALDH1A1 (0.62) RAB9AMAPTNPC1ALDH1A1SMN1; SMN2
SCHEMBL7001753 0.83 FLT3 (0.69) RAB9AMAPTNPC1ALDH1A1SMN1; SMN2
SCHEMBL26424875 0.82 HPGD (0.66) MAPTALDH1A1KDM4ETP53HPGD
SCHEMBL7002469 0.81 ALDH1A1 (0.60) RAB9AMAPTNPC1ALDH1A1SMN1; SMN2
SCHEMBL7003934 0.80 ALDH1A1 (0.70) RAB9AMAPTNPC1ALDH1A1SMN1; SMN2
SCHEMBL7004549 0.80 FLT3 (0.68) RAB9AMAPTNPC1ALDH1A1SMN1; SMN2
SCHEMBL7003132 0.79 ALDH1A1 (0.64) RAB9AMAPTNPC1ALDH1A1SMN1; SMN2
SCHEMBL8288650 0.75 ALDH1A1 (0.68) RAB9AMAPTNPC1ALDH1A1SMN1; SMN2
SCHEMBL8289840 0.75 NPC1 (0.77) RAB9AMAPTNPC1ALDH1A1SMN1; SMN2
SCHEMBL6998742 0.75 FLT3 (0.83) RAB9AMAPTNPC1ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1294707-A2 THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM Pharmacia Italia S.p.A. (IT) 2003-03-26 EP claimed
US-6414013-B1 KINASE INHIBITORS; ANTICANCER AGENTS PHARMACIA & UPJOHN S.P.A. (IT) 2002-07-02 US claimed
WO-2001098290-A2 THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM PHARMACIA ITALIA S.P.A. (IT) 2001-12-27 WO claimed