SCHEMBL7003132

SCHEMBL7003132

Cc1sc(NC(=O)c2cc(Cl)cc(Cl)c2)c(C(N)=O)c1C

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 11/20 0.64
MAPT P10636 9/20 0.64
RAB9A P51151 6/20 0.64
NPC1 O15118 5/20 0.64
SMN1; SMN2 Q16637 4/20 0.64
KDM4E B2RXH2 3/20 0.64
TP53 P04637 2/20 0.64
MAPK1 P28482 2/20 0.64
GRIN2C Q14957 2/20 0.64
NFKB1 P19838 1/20 0.64
CASP1 P29466 1/20 0.64
CASP7 P55210 1/20 0.64
NFKB2 Q00653 1/20 0.64
RELA Q04206 1/20 0.64
NPSR1 Q6W5P4 1/20 0.64
FLT3 P36888 1/20 0.63
HPGD P15428 7/20 0.56
HSD17B10 Q99714 2/20 0.56
MAPK10 P53779 1/20 0.56
AIP O00170 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7004549 0.84 FLT3 (0.68) ALDH1A1MAPTRAB9ANPC1SMN1; SMN2
SCHEMBL7003164 0.82 FLT3 (0.70) ALDH1A1MAPTRAB9ANPC1SMN1; SMN2
SCHEMBL20838909 0.79 ADORA1 (0.61) ALDH1A1MAPTRAB9ANPC1SMN1; SMN2
SCHEMBL6998742 0.79 FLT3 (0.83) ALDH1A1MAPTRAB9ANPC1SMN1; SMN2
SCHEMBL7003934 0.79 ALDH1A1 (0.70) ALDH1A1MAPTRAB9ANPC1SMN1; SMN2
SCHEMBL6999632 0.79 RAB9A (0.62) ALDH1A1MAPTRAB9ANPC1SMN1; SMN2
SCHEMBL7673789 0.79 ALDH1A1 (0.62) ALDH1A1MAPTRAB9ANPC1SMN1; SMN2
SCHEMBL7902809 0.78 GRIN2C (1.00) ALDH1A1MAPTRAB9ANPC1SMN1; SMN2
SCHEMBL7002672 0.78 FLT3 (1.00) ALDH1A1MAPTRAB9ANPC1SMN1; SMN2
SCHEMBL8288778 0.77 FLT3 (0.73) ALDH1A1MAPTRAB9ANPC1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1294707-A2 THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM Pharmacia Italia S.p.A. (IT) 2003-03-26 EP claimed
US-6414013-B1 KINASE INHIBITORS; ANTICANCER AGENTS PHARMACIA & UPJOHN S.P.A. (IT) 2002-07-02 US claimed
WO-2001098290-A2 THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM PHARMACIA ITALIA S.P.A. (IT) 2001-12-27 WO claimed