SCHEMBL1189632

SCHEMBL1189632

CCOC(=O)Nc1ccccc1Cl

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.77
HPGD P15428 1/20 0.62
SMN1; SMN2 Q16637 3/20 0.58
MEN1 O00255 4/20 0.57
KMT2A Q03164 4/20 0.57
MAPT P10636 2/20 0.56
NPC1 O15118 2/20 0.56
RAB9A P51151 2/20 0.56
LMNA P02545 1/20 0.56
MAPK1 P28482 1/20 0.56
CYP1A2 P05177 1/20 0.56
CYP2C9 P11712 1/20 0.56
CYP2C19 P33261 1/20 0.56
GAA P10253 1/20 0.56
TSHR P16473 1/20 0.56
NLRP3 Q96P20 1/20 0.55
TDP1 Q9NUW8 1/20 0.54
MAPK13 O15264 1/20 0.53
MAPK12 P53778 1/20 0.53
MAPK11 Q15759 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11295189 0.89 ALDH1A1 (0.62) ALDH1A1HPGDSMN1; SMN2MEN1KMT2A
SCHEMBL28401182 0.87 ALDH1A1 (0.72) ALDH1A1HPGDSMN1; SMN2MEN1KMT2A
SCHEMBL3803167 0.87 ALDH1A1 (0.77) ALDH1A1HPGDSMN1; SMN2MEN1KMT2A
SCHEMBL21059173 0.87 SMN1; SMN2 (0.63) ALDH1A1SMN1; SMN2MEN1KMT2ANPC1
SCHEMBL3788964 0.85 ALDH1A1 (0.75) ALDH1A1HPGDSMN1; SMN2MAPTCYP1A2
SCHEMBL23727249 0.85 ALDH1A1 (0.57) ALDH1A1HPGDMEN1KMT2AMAPT
SCHEMBL30130809 0.85 ALDH1A1 (0.57) ALDH1A1HPGDMEN1KMT2AMAPT
SCHEMBL3784358 0.84 ALDH1A1 (0.73) ALDH1A1HPGDSMN1; SMN2MEN1KMT2A
SCHEMBL21059156 0.84 SMN1; SMN2 (0.66) ALDH1A1HPGDSMN1; SMN2MEN1KMT2A
SCHEMBL18415553 0.83 GPR35 (0.74) ALDH1A1HPGDSMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115989220-A Amido cyclohexanoic acid derivatives as LPA receptor inhibitors 奇斯药制品公司 2023-04-18 CN disclosed
EP-3508473-B1 METHOD FOR PRODUCING CARBAMIC ACID ESTER AIST (JP) 2021-05-26 EP disclosed
US-10752579-B2 Production method of carbamic acid ester NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2020-08-25 US disclosed
EP-3508473-A1 METHOD FOR PRODUCING CARBAMIC ACID ESTER National Institute of Advanced Industrial Science and Technology (JP) 2019-07-10 EP disclosed
US-20190185420-A1 PRODUCTION METHOD OF CARBAMIC ACID ESTER NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2019-06-20 US disclosed
US-20110155660-A1 MODIFIED MEMBRANE DOW GLOBAL TECHNOLOGIES LLC 2011-06-30 US disclosed
US-7882963-B2 modifying polyamide discriminating layer ( e.g metaphenylene diamine- trimesoyl chloride monomers) with aminoacetophenone or aminothiophenol; fouling resistant surface, improved salt rejection, antimicrobial properties, improved solute, and/or small organics rejection; for water purification DOW GLOBAL TECHNOLOGIES INC. (US) 2011-02-08 US disclosed
US-20100087680-A1 METHOD FOR PRODUCING BIARYL COMPOUND SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2010-04-08 US disclosed
US-20090159527-A1 MODIFIED MEMBRANE DOW GLOBAL TECHNOLOGIES LLC 2009-06-25 US disclosed
US-7439382-B2 4-alkyl-2-haloaniline derivatives and process for producing the same MEIJI SEIKA KAISHA, LTD. (JP) 2008-10-21 US disclosed
WO-2007133362-A1 MODIFIED MEMBRANE DOW GLOBAL TECHNOLOGIES INC. (US) 2007-11-22 WO disclosed
US-6939887-B2 Benzimidazolidinone derivatives SUMITOMO PHARMACEUTICALS CO., LTD. (JP) 2005-09-06 US disclosed
US-20050143454-A1 4-Alkyl-2-haloaniline derivative and process and process for producing the same MEIJI SEIKA PHARMA CO., LTD. (JP) 2005-06-30 US disclosed
EP-1506954-A1 4-ALKYL-2-HALOANILINE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME MEIJI SEIKA KAISHA LTD. (JP) 2005-02-16 EP disclosed
US-20040142850-A1 Benzimidazolidinone derivatives DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2004-07-22 US disclosed
EP-1364945-A1 BENZIMIDAZOLIDINONE DERIVATIVES SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2003-11-26 EP disclosed
EP-0032733-B1 PROCESS FOR PREPARING POLYMETHYLENE POLYPHENYL POLYCARBAMATES MITSUI TOATSU CHEMICALS, Inc. (JP) 1984-06-13 EP disclosed
US-4328354-A Preparation of methylene-bis-phenylcarbamic acid esters and polymethylene-polyphenylcarbamic acid esters BASF AKTIENGESELLSCHAFT (DE) 1982-05-04 US disclosed
US-4282370-A Preparation of methylene-bis-phenylcarbamic acid esters and of polymethylene-polyphenylcarbamic acid esters BASF AKTIENGESELLSCHAFT (DE) 1981-08-04 US disclosed
EP-0032733-A1 Process for preparing polymethylene polyphenyl polycarbamates MITSUI TOATSU CHEMICALS, Inc. (JP) 1981-07-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100087680-A1 METHOD FOR PRODUCING BIARYL COMPOUND NISCH, BLVRB, BBOX1 ALDH1A1 4339/4885HPGD 2790/4885SMN1; SMN2 4524/4885
US-20040142850-A1 Benzimidazolidinone derivatives GHSR, GHRHR, PRLHR ALDH1A1 2586/4885HPGD 2766/4885SMN1; SMN2 3071/4885
US-20050143454-A1 4-Alkyl-2-haloaniline derivative and process and process for producing the same NAT1, CYP4X1, HAX1 ALDH1A1 441/4885HPGD 1153/4885SMN1; SMN2 4051/4885
US-20190185420-A1 PRODUCTION METHOD OF CARBAMIC ACID ESTER CA2, CA7, CA4 ALDH1A1 3215/4885HPGD 3008/4885SMN1; SMN2 3068/4885
US-10752579-B2 Production method of carbamic acid ester CA2, CA7, CA4 ALDH1A1 3215/4885HPGD 3008/4885SMN1; SMN2 3068/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.