Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.56 |
| ▸ | CYBB | P04839 | 1/20 | 0.56 |
| ▸ | NOX3 | Q9HBY0 | 1/20 | 0.56 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KIF11 | P52732 | 3/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | SCN4A | P35499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002208 | 0.89 | NOX1 (0.54) | NOX1CYBBNOX3NOX4MAPT | |
| SCHEMBL6998043 | 0.81 | NOX1 (0.56) | NOX1CYBBNOX3NOX4MAPT | |
| SCHEMBL5670583 | 0.75 | NOX1 (0.52) | NOX1CYBBNOX3NOX4MAPT | |
| Phenothiazine SCHEMBL6532335 | 0.72 | NOX1 (1.00) | NOX1CYBBNOX3NOX4MAPT | |
| SCHEMBL560225 | 0.72 | NOX1 (1.00) | NOX1CYBBNOX3NOX4MAPT | |
| SCHEMBL29475150 | 0.72 | NOX1 (1.00) | NOX1CYBBNOX3NOX4MAPT | |
| SCHEMBL23059883 | 0.71 | NOX1 (0.69) | NOX1CYBBNOX3NOX4MAPT | |
| SCHEMBL10193005 | 0.71 | MAPT (0.65) | NOX1CYBBNOX3NOX4MAPT | |
| Benzene SCHEMBL29242186 | 0.71 | NOX1 (0.97) | NOX1CYBBNOX3NOX4MAPT | |
| SCHEMBL11375009 | 0.69 | NOX1 (0.69) | NOX1CYBBNOX3NOX4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015437-B1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING AG (DE) | 2003-12-03 | — | — | EP | disclosed |
| US-6365736-B1 | TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-02 | — | — | US | disclosed |